Aspartame can affect the levels & balance of all these transmitters. It impairs the absorption of L-tryptophan, the major precursor in the synthesis of serotonin.

The phenylalanine from the dipeptide component of the aspartame molecule, is a major precursor in the norepinephrine-dopamine synthetic pathway. Recent research demonstrated that aspartame reduces acetylcholinesterase, an enzyme which breaks down acetylcholine - a key player in the central nervous system, with an important role in cognition and memory, and with a reciprocal, inhibitory relationship with dopamine.

We are not sophisticated enough at this point in time to fully understand all the implications of the neurochemical changes induced by aspartame, but as a busy clinician I see the profound impact on patients' lives on a daily basis. It can both produce and aggravate depression, in certain patients it can trigger manic episodes, it can produce or aggravate panic attacks. Some of my patients have experienced a complete cessation of panic attacks and needed no further treatment after they completely eliminated aspartame from their diet. Certain schizophrenic patients have experienced fewer auditory hallucinations or needed less antipsychotic medication after the elimination of aspartame.

It is essential that there be much greater awareness of the hazards of this highly toxic substance!

Ralph G. Walton, M.D.,
Medical Director, Safe Harbor Behavioral Health
Professor of Clinical Psychiatry, Northeastern Ohio
Universities College of Medicine
Adjunct Professor Of Psychiatry, Lake Erie College of
Osteopathic Medicine

Dr. Walton's aspartame study: "Adverse Reactions to Aspartame: Double-Blind Challenge in Patients from a Vulnerable Population"

Dr. Walton's research on Scientific Peer Reviewed Studies and Funding